"Las Voces de los Apalaches" will be an evening to help celebrate the "Year of Mexico!" First will be a dramatic presentation in Worsham Theater, beginning at 7 p.m. To follow the dramatic presentation is the band Apalatin.
Revisiting Rock Fences of the Bluegrass
Revisiting Rock Fences of the Bluegrass
Revisiting Rock Fences of the Bluegrass
This panel of historians and representatives of federal volunteer programs will discuss 50 years of US War on Poverty investments in social change in Appalachia throuh youth service programs, from the Appalachian Volunteers in the 1960s, to current Teach for America and VISTA volunteers. Panelists will provide an overview of the larger policy context, experiences as volunteers, community critiques, and the effects of the recent federal sequestration.
Title: Informatics and Modeling Platform for Stable Isotope-Resolve Metabolomics
Abstract: Recent advances in stable isotope-resolved metabolomics (SIRM) are enabling orders-of-magnitude increase in the number of observable metabolic traits (a metabolic phenotype) for a given organism or community of organisms. Analytical experiments that take only a few minutes to perform can detect stable isotope-labeled variants of thousands of metabolites. Thus, unique metabolic phenotypes may be observable for almost all significant biological states, biological processes, and perturbations. Currently, the major bottleneck is the lack of data analysis that can properly organize and interpret this mountain of phenotypic data as highly insightful biochemical and biological information for a wide range of biological research applications. To address this limitation, we are developing bioinformatic, biostatistical, and systems biochemical tools, implemented in an integrated data analysis platform, that will directly model metabolic networks as complex inverse problems that are optimized and verified by experimental metabolomics data. This integrated data analysis platform will enable a broad application of SIRM from the discovery of specific metabolic phenotypes representing biological states of interest to a mechanism-based understanding of a wide range of biological processes with particular metabolic phenotypes.
Title: Informatics and Modeling Platform for Stable Isotope-Resolve Metabolomics
Abstract: Recent advances in stable isotope-resolved metabolomics (SIRM) are enabling orders-of-magnitude increase in the number of observable metabolic traits (a metabolic phenotype) for a given organism or community of organisms. Analytical experiments that take only a few minutes to perform can detect stable isotope-labeled variants of thousands of metabolites. Thus, unique metabolic phenotypes may be observable for almost all significant biological states, biological processes, and perturbations. Currently, the major bottleneck is the lack of data analysis that can properly organize and interpret this mountain of phenotypic data as highly insightful biochemical and biological information for a wide range of biological research applications. To address this limitation, we are developing bioinformatic, biostatistical, and systems biochemical tools, implemented in an integrated data analysis platform, that will directly model metabolic networks as complex inverse problems that are optimized and verified by experimental metabolomics data. This integrated data analysis platform will enable a broad application of SIRM from the discovery of specific metabolic phenotypes representing biological states of interest to a mechanism-based understanding of a wide range of biological processes with particular metabolic phenotypes.
Title: Smoothness of isometries between subRiemannian manifolds
Abstract: In a joint work with Enrico Le Donne (Jyvaskyla, Finland), we show that the group of isometries (i.e., distance-preserving homeomorphisms) of an equiregular subRiemannian manifold is a finite-dimensional Lie group of smooth transformations. The proof is based on a new PDE argument, in the spirit of harmonic coordinates, establishing that in an arbitrary subRiemannian manifold there exists an open dense subset where all isometries are smooth.
Title: Higher-order analogues of the exterior derivative complex
Abstract: I will discuss some earlier joint work with E. M. Stein concerning div-curl type inequalities for the exterior derivative operator and its adjoint in Euclidean space R^n. I will then present various higher-order generalizations of the notion of exterior derivative, and discuss some recent div-curl type estimates for such operators. Part of this work is joint with A. Raich.
Title: Higher-order analogues of the exterior derivative complex
Abstract: I will discuss some earlier joint work with E. M. Stein concerning div-curl type inequalities for the exterior derivative operator and its adjoint in Euclidean space R^n. I will then present various higher-order generalizations of the notion of exterior derivative, and discuss some recent div-curl type estimates for such operators. Part of this work is joint with A. Raich.
